The SignalHub Quantitative Think Tank CenterGhostface killer is taking yet another stab at the box office as Scream 6 has arrived in theatres. It's a sequel to last year's reboot – or requel – of everyone's favorite deeply meta slasher franchise. Starring Jenna Ortega and Melissa Barerra, Scream 6 takes the characters who managed to survive the last Scream movie out of bucolic Woodsboro and into the urban jungle of New York City.